Colorado, 1918. World War I is raging overseas, but it's the home front battling for survival. With the Spanish Flu rampant, Denver's schools are converted into hospitals, churches and funeral homes are closed, and nightly horse-drawn wagons collect corpses left in the street. Sisters Helen and Lutie have moved to Denver from Ohio after their parents' death. Helen, a nurse, and Lutie, a carefree advertising designer at Neusteter's department store, share a small, neat house and each finds a local beau, for Helen a doctor, for Lutie a young student who soon enlists. They make a modest income from a rental apartment in the basement. When their tenant dies from the flu, the sisters are thrust into caring the woman's small daughter, Dorothy. Soon after, Lutie comes home from work and discovers a dead man on their kitchen floor and Helen standing above the body, an icepick in hand. She has no doubt Helen killed the man, Dorothy's father, in self-defense, but she knows that will be hard to prove. They decide to leave the body in the street, hoping to disguise it as a victim of the flu.