In Pursuit of Memory: The Fight Against Alzheimer's
(OverDrive MP3 Audiobook, OverDrive Listen)
Description
Alzheimer's is the great global epidemic of our time, affecting millions worldwide — there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure.
Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then — a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world — many of whom he's worked with — and the brave patients and families who have changed the way that researchers think about the disease.
This compelling insider's account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now.
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Joseph Jebelli. (2017). In Pursuit of Memory: The Fight Against Alzheimer's. Unabridged Hachette Audio.
Chicago / Turabian - Author Date Citation (style guide)Joseph Jebelli. 2017. In Pursuit of Memory: The Fight Against Alzheimer's. Hachette Audio.
Chicago / Turabian - Humanities Citation (style guide)Joseph Jebelli, In Pursuit of Memory: The Fight Against Alzheimer's. Hachette Audio, 2017.
MLA Citation (style guide)Joseph Jebelli. In Pursuit of Memory: The Fight Against Alzheimer's. Unabridged Hachette Audio, 2017.
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- For readers of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases — Alzheimer's — from its discovery more than 100 years ago to today's race towards a cure.
Alzheimer's is the great global epidemic of our time, affecting millions worldwide — there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure.
Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then — a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world — many of whom he's worked with — and the brave patients and families who have changed the way that researchers think about the disease.
This compelling insider's account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now. - reviews
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Starred review from September 4, 2017
The struggle to cure a cruel and increasingly common disease leads down intricate pathways of scientific discovery in this fascinating primer. Neuroscientist Jebelli recalls his grandfather’s decline from Alzheimer’s disease and meets other victims of the neurodegenerative illness, projected to become the second leading cause of death by 2050. He describes Alzheimer’s progression from forgetfulness to a loss of personality and inability to recognize family members to comprehensive mental failure, with sufferers unable to speak or even swallow. But the book’s heart is his account of scientists’ efforts to understand Alzheimer’s, from its mysterious telltale clusters of beta-amyloid protein to its hereditary underpinnings. In addition to specialists, Jebelli visits families whose tragically high rates of Alzheimer’s led to the identification of genetic mutations that cause the disease. The saga is full of hopeful—and frustrating—turns as ingenious new research suggests potential treatments that prove effective in mice but disappointing in humans. One promising, if ghoulish, approach is to transfuse plasma from young people into old, which seems to have remarkable restorative effects; alas, there’s too little young blood available to treat most Alzheimer’s cases. Jebelli’s exploration of the vexed science of Alzheimer’s is lucid and emotionally rich in its portrayal of those who investigate the illness and those who endure it.
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- content: Joseph Jebelli's interest in Alzheimer's research is personal. He recalls his grandfather's struggle with memory loss as he looks into the history of the illness and developments in the field. Thomas Judd's narration reflects that personal concern, keeping listeners interested through the tangles of study results and shifts in research budgets. Listeners will want to stay with the work until they get to the recent hopeful developments. Jebelli adds humanity to the story whenever possible, even taking a dementia test himself. He also takes listeners on a tour of a Swedish home for elderly dementia patients and describes patients' struggles with simple tasks. Everyone ages, and Jebelli makes the health of aging minds an intriguing and relevant topic. J.A.S. © AudioFile 2018, Portland, Maine
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Starred review from September 1, 2017
Alzheimer's disease has stymied attempts at a cure for generations, but exciting advances in biomedical technologies have yielded new understanding of why the disease occurs and how to eradicate it.By conservative estimates, Alzheimer's affects 47 million people worldwide, yet its pathology remains largely unknown. Jebelli, who was inspired to become a neuroscientist after his grandfather was afflicted, tells the story of the disease's devastating impact through the voices of patients and their families. He further unpacks the evolving scientific understanding of the disease by traveling the globe to interview the intrepid researchers who have dedicated their careers to Alzheimer's, attempting to characterize its causes and symptoms in order to devise effective treatment options. While it has long been understood that abnormal "plaques" and "tangles" in the brain erode neuronal function, resulting in progressive dementia, why these abnormalities occur remains mysterious. Also opaque is how to prevent them, even as diagnostic techniques grow more sophisticated, identifying biomarkers and other signs of the disease sometimes years before the onset of symptoms. Yet biomedical innovations such as stem cell engineering and Clustered Regularly Interspaced Short Palindromic Repeats offer real hope that a means to reverse symptoms or eliminate the disease may be within reach. Intriguing, as well, are the clinical trials that suggest certain lifestyle changes--the familiar trio of diet, exercise, and mental engagement--may be our best bet at wholesale prevention. An elegant and precise writer, the author follows every lead for a cure with the panache of a detective novelist, giving readers much to hope for despite the devastation Alzheimer's has left in its wake. Based on his meticulous and wide-ranging research, he makes a convincing argument that Alzheimer's will be defeated in the decades to come. Jebelli analyzes every facet of Alzheimer's with personal empathy and scientific rigor, a combination that makes for enthralling reading.COPYRIGHT(2017) Kirkus Reviews, ALL RIGHTS RESERVED.
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Alzheimer's is the great global epidemic of our time, affecting millions worldwide — there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure.
Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then — a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through... - sortTitle
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