The series had a simple premise: The coyote, who was very hungry, tried to catch the Road Runner, who was very fast. Wile E. would try anything to catch his prey, utilizing a wide variety of products from the Acme Company, including rocket skates, giant magnets and foot springs. Regardless of the scheme, it would always backfire, and Wile E. would end up trapping, flattening, or blowing himself up.
La serie tenía una premisa simple: el coyote, que tenía mucha hambre, intentó atrapar al Correcaminos, que era muy rápido. Wile E. trataría todo para atrapar a su presa, utilizando una amplia variedad de productos de la compañía Acme, incluyendo patines cohete, imanes gigantes y resortes de pie. Independientemente del esquema, siempre sería contraproducente, y Wile E. acabaría atrapandose, aplanandose o explotándose a sí mismo.