Told from separate viewpoints, teens Scam, Crash, Flicker, Anonymous, Bellwether, and Kelsie, all born in the year 2000 and living in Cambria, California, have superhuman abilities that give them interesting but not heroic lives until they must work as a community to respond to a high stakes crisis.

The Zeroes are scattered, on the run, and desperate when challenges from within and from the world around them guarantee an epic showdown.