Set in early 1950s rural South Carolina, One Good Mama Bone chronicles Sarah Creamer's quest to find her "mama bone," after she is left to care for a boy who is not her own but instead is the product of an affair between her husband and her best friend and neighbor, a woman she calls "Sister." When her husband drinks himself to death, Sarah, a dirt-poor homemaker with no family to rely on and the note on the farm long past due, must find a way for her and young Emerson Bridge to survive. But the more daunting obstacle is Sarah's fear that her mother's words, seared in her memory since she first heard them at the age of six, were a prophesy, "You ain't got you one good mama bone in you, girl."