Thirteen-year-old Dan Cahill and his older sister, Amy, are the latest guardians of the Clues -- thirty-nine ingredients in a serum that transforms whomever takes it into the most powerful person on earth. They think they've done everything right, but a tiny mistake leads to catastrophe. The serum is missing and Dan and Amy have to get it back and stop who stole it ... before it's game over.

With Amy and Dan still in pursuit of Pierce, Amy does something unthinkable that sends shockwaves through her family.