On the eve of her marriage to a stranger, sixteen-year-old Lady Jane Grey is swept in a conspiracy to usurp the throne from her cousin.

Welcome to 1876 America, a place bursting with gunslingers, outlaws, and garou -- better known as werewolves. And where there are garou, there're hunters: the one and only Calamity Jane, to be precise, along with her fellow stars of Wild Bill's Traveling Show, Annie Oakley and Frank the Pistol Prince Butler. After a garou hunt goes south and Jane finds a suspicious-like bite on her arm, she turns tail for Deadwood, where there's talk of a garou cure....